The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2023
Filed:
Aug. 01, 2018
Applicants:
China Pharmaceutical University, Nanjing, CN;
Hefei Industrial Pharmaceutical Institute Co., Ltd., Hefei, CN;
Inventors:
Yungen Xu, Nanjing, CN;
Qihua Zhu, Nanjing, CN;
Junwei Wang, Nanjing, CN;
Hui Li, Nanjing, CN;
Zhaoxing Chu, Hefei, CN;
Guangwei He, Hefei, CN;
Assignee:
CHINA PHARMACEUTICAL UNIVERSITY, Nanjing, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 35/00 (2006.01); B01J 31/28 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 35/00 (2018.01); B01J 31/28 (2013.01);
Abstract
The present disclosure relates to the field of pharmaceutical chemistry, in particular to a class of PARP/PI3K double-target inhibitors (I) containing structures of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine and phthalazin-1(2H)-one and a preparation method thereof. As proved by pharmacodynamic tests, the compounds of the present disclosure have PARP/PI3K double-target inhibitory activity and can be used for anti-tumor.