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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11571635 B1

PDFFull Text
Date of Patent:
Feb. 07, 2023

Filed:

Mar. 23, 2016

Liquid chromatography system, a device, and a method

Applicant:

Cytiva Sweden Ab, Uppsala, SE;

Inventors:

Bjorn Markus Olovsson, Uppsala, SE;

Anders Ljunglof, Uppsala, SE;

Karol Maciej Lacki, Uppsala, SE;

Assignee:

Cytiva Sweden AB, Uppsala, SE;

Attorney:

Eversheds Sutherland (US) LLP

Primary Examiner:

Rebecca M Fritchman

Int. Cl.
CPC ...
B01D 15/00 (2006.01); B01D 15/38 (2006.01); B01D 15/18 (2006.01); B01D 15/14 (2006.01); G01N 30/46 (2006.01); C07K 1/22 (2006.01); C12N 7/00 (2006.01); G01N 30/20 (2006.01); G01N 30/88 (2006.01);
U.S. Cl.
CPC ...
B01D 15/1864 (2013.01); B01D 15/14 (2013.01); B01D 15/1807 (2013.01); B01D 15/3809 (2013.01); C07K 1/22 (2013.01); C12N 7/00 (2013.01); G01N 30/465 (2013.01); G01N 2030/208 (2013.01); G01N 2030/8813 (2013.01);
Abstract

The present invention relates to a liquid chromatography system for the separation of bio-molecules in a fluid including at least two unit operations, wherein the first unit operation is a step of multi-column chromatography and the second unit operation is a step modifying said bio-molecules and/or the fluid, wherein the modification comprises feeding the fluid resulting from the last chromatography column of the first unit operation into a system comprising at least two containers, wherein each container has a volume and a moveable sidewall arranged to divide the volume into a first sub-volume and a second sub-volume, and each container comprises a first port connected to the first volume and a second port connected to the second sub-volume. The invention also relates to a virus inactivation device for a chromatography system according to the invention, which enables continuous or semi-continuous processing of biomolecules, as well as a method of using such a device.

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