The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 07, 2023

Filed:

Sep. 29, 2017
Applicants:

The University of Chicago, Chicago, IL (US);

Uchicago Argonne, Llc, Chicago, IL (US);

Inventors:

John C. Alverdy, Glenview, IL (US);

Matthew Tirrell, Chicago, IL (US);

Olga Y. Zaborina, Brookfield, IL (US);

Jun Mao, Chicago, IL (US);

Wei Chen, Chicago, IL (US);

Assignee:

The University of Chicago, Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/77 (2006.01); C08G 65/335 (2006.01); C08G 81/00 (2006.01); A61P 31/04 (2006.01); A61P 1/00 (2006.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); A61K 31/765 (2006.01); A61K 9/00 (2006.01); A61K 31/80 (2006.01);
U.S. Cl.
CPC ...
A61K 31/77 (2013.01); A61K 9/0095 (2013.01); A61K 31/765 (2013.01); A61K 31/80 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61P 1/00 (2018.01); A61P 31/04 (2018.01); C08G 65/3353 (2013.01); C08G 81/00 (2013.01);
Abstract

The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g.,, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.


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