The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2023

Filed:

Mar. 31, 2021
Applicant:

Braskem S.a., Sao Paulo, BR;

Inventors:

Paulo Moises Raduan Alexandrino, Campinas, BR;

Iuri Estrada Gouvea, Campinas, BR;

Veronica Leite Queiroz, Campinas, BR;

Felipe Cicaroni Fernandes, Campinas, BR;

Bárbara Mano, Campinas, BR;

Assignee:

BRASKEM S.A., Sao Paulo, BR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 17/04 (2006.01); C07D 307/68 (2006.01); C12N 9/88 (2006.01); C12N 9/04 (2006.01); C12N 9/02 (2006.01); C12N 9/08 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
C12P 17/04 (2013.01); C07D 307/68 (2013.01); C12N 9/0006 (2013.01); C12N 9/0008 (2013.01); C12N 9/0065 (2013.01); C12N 9/16 (2013.01); C12N 9/88 (2013.01); C12Y 101/01 (2013.01); C12Y 102/01 (2013.01); C12Y 101/01001 (2013.01); C12Y 101/03 (2013.01); C12Y 102/01003 (2013.01); C12Y 102/01004 (2013.01); C12Y 102/01005 (2013.01); C12Y 207/01 (2013.01); C12Y 301/03 (2013.01); C12Y 402/03 (2013.01);
Abstract

The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.


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