The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2023

Filed:

Dec. 14, 2017
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Novome Biotechnologies, Inc., Daly City, CA (US);

Inventors:

Justin L. Sonnenburg, Redwood City, CA (US);

Weston R. Whitaker, Daly City, CA (US);

Elizabeth Stanley, Portola Valley, CA (US);

William C. DeLoache, Oakland, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/741 (2015.01); C12N 15/52 (2006.01); A61P 1/00 (2006.01); C12N 1/21 (2006.01); C12N 15/74 (2006.01); C12N 9/24 (2006.01); C12N 1/20 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); A61K 35/741 (2013.01); A61P 1/00 (2018.01); C12N 1/20 (2013.01); C12N 15/52 (2013.01); C12N 15/74 (2013.01); C12Y 302/01178 (2013.01);
Abstract

Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome.


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