The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
Dec. 18, 2019
Applicant:
King's College London, London, GB;
Inventors:
John Maher, London, GB;
Ana Catarina Parente Pereira Puri, London, GB;
Richard Esmond Beatson, London, GB;
Assignee:
KING'S COLLEGE LONDON, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61K 31/7068 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0636 (2013.01); A61K 31/7068 (2013.01); A61K 35/17 (2013.01); C12N 5/0637 (2013.01); C12N 2500/42 (2013.01); C12N 2501/15 (2013.01); C12N 2501/20 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/999 (2013.01); C12N 2506/11 (2013.01);
Abstract
A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector γδ T-cells having therapeutic activity against malignant disease is favored. The use of TGF-β in the production of effector cells in particular Vγ9Vδ2 T-cells is also described and claimed.