The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
Jun. 18, 2020
Applicant:
Fresenius Kabi Ipsum S.r.l., Cassina de' Pecchi, IT;
Inventors:
Andrea Orlandin, Cassina de' Pecchi, IT;
Antonio Ricci, Cassina de' Pecchi, IT;
Walter Cabri, Cassina de' Pecchi, IT;
Steve McIntyre, Craigavon, GB;
Alex Saunders, Belfast, GB;
Assignee:
Fresenius Kabl iPSUM S.R.L., Milan, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/605 (2006.01); C07K 1/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); C07K 1/063 (2013.01);
Abstract
The present invention provides an improved process for the preparation of high purity glucagon comprising the use of Xmb-protected amino acids, wherein may Xmb include, e.g., 2,4,6-trimethoxybenzyl, 2,4-dimethoxybenzyl, or 2-hydroxy-4-methoxybenzyl. The process also comprises the use of building blocks such as pseudoprolines to avoid aggregation and obtain the product in high yield and purity.