The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
Jul. 27, 2020
Applicant:
Zata Pharmaceuticals, Inc, Worcester, MA (US);
Inventors:
David R. Tabatadze, Worcester, MA (US);
Ivan B. Yanachkov, Shrewsbury, MA (US);
Assignee:
ZATA Pharmaceuticals, Inc, Worcester, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); A61K 31/7088 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); A61K 31/7088 (2013.01); C07H 19/10 (2013.01); C07H 19/20 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01);
Abstract
Compositions and compounds of nucleoside phosphoramidites and modified oligonucleotides, each comprising one or more charge-neutralizing moieties according to the formula V The nucleoside phosphoramidites permit facile attachment of the neutralizing moieties on the backbones of the modified oligonucleotides. The modified oligonucleotides can be used as therapeutic agents (i.e., oligotherapeutics) for the treatment of cancer, autoimmune disorders, genetic diseases, infectious diseases, neurological diseases, inflammatory diseases, metabolic diseases and others.