The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 31, 2023

Filed:

Jun. 16, 2022
Applicants:

The Regents of the University of California, Oakland, CA (US);

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

David V. Schaffer, Danville, CA (US);

John G. Flannery, Berkeley, CA (US);

William A. Beltran, Philadelphia, PA (US);

Leah C. Byrne, San Francisco, CA (US);

Meike Visel, El Cerrito, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 7/00 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0091 (2013.01); A61K 9/0048 (2013.01); A61K 48/0075 (2013.01); C12N 7/00 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01);
Abstract

The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.


Find Patent Forward Citations

Loading…