The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
Sep. 18, 2020
Applicant:
Effector Therapeutics, Inc., San Diego, CA (US);
Inventors:
Kevin R. Webster, San Diego, CA (US);
Rajesh Sharma, San Diego, CA (US);
Gary Chiang, San Diego, CA (US);
Assignee:
eFFECTOR Therapeutics Inc., San Diego, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 35/17 (2015.01); C07K 14/74 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 14/16 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 495/20 (2006.01); C07D 491/20 (2006.01); C07D 471/20 (2006.01); A61K 31/501 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 31/501 (2013.01); A61P 35/00 (2018.01); C07D 471/04 (2013.01); C07D 471/20 (2013.01); C07D 487/04 (2013.01); C07D 491/20 (2013.01); C07D 495/20 (2013.01); C07K 14/162 (2013.01); C07K 14/7051 (2013.01); C07K 14/70514 (2013.01); C07K 14/70517 (2013.01); C07K 14/70539 (2013.01); C07K 14/70564 (2013.01); C07K 14/70589 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); A61K 45/06 (2013.01); C12N 2501/727 (2013.01);
Abstract
The present disclosure relates to genetically modified T cells comprising a transgene encoding an engineered antigen specific receptor, wherein expression of an endogenous gene selected from MNK1, MNK2, or both are inhibited in the genetically modified T cell in order to enhance central memory T cell subsets in cellular immunotherapy compositions.