The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 2023
Filed:
Dec. 29, 2017
Nanjing Legend Biotech Co., Ltd., Jiangsu, CN;
Xiaohu Fan, Edmonton, CA;
Qiuchuan Zhuang, Jiangsu, CN;
Pingyan Wang, Anhui, CN;
Lei Yang, Anhui, CN;
Xiujun Zheng, Jiangsu, CN;
Jiaying Hao, Jiangsu, CN;
Shaobo Liu, Jiangsu, CN;
Nanjing Legend Biotech Co., Ltd., Jiangsu, CN;
Abstract
Disclosed herein is a novel chimeric antigen receptor and use thereof. The novel chimeric antigen receptor consists of a signal peptide, an antigen binding domain, a transmembrane region, and an intracellular signal domain, and comprises a 4-1BB signal peptide and/or a 4-1BB molecular transmembrane region. Nucleic acid sequences of various chimeric antigen receptors are separated and purified and provided is a chimeric antigen receptor and a CAR-T cell which are specific for a CD19 malignant tumor antigen. In the malignant tumor killing test of hematological cell lines, the ability of immune cells to target and recognize tumor cells is significantly enhanced, and the killing activity against tumor cells is also enhanced.