The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 24, 2023

Filed:

May. 18, 2021
Applicant:

National Technology & Engineering Solutions of Sandia, Llc, Albuquerque, NM (US);

Inventors:

Samuel Coradetti, Berkeley, CA (US);

John Michael Gladden, Alameda, CA (US);

Di Liu, Emeryville, CA (US);

Gina Marie Geiselman, Alameda, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 7/6409 (2022.01); C12P 7/6436 (2022.01); C12N 9/04 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C12N 9/88 (2006.01); C07K 14/39 (2006.01); C12N 9/00 (2006.01); C12N 1/15 (2006.01);
U.S. Cl.
CPC ...
C12P 7/6409 (2013.01); C07K 14/39 (2013.01); C12N 9/0006 (2013.01); C12N 9/0008 (2013.01); C12N 9/1029 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12P 7/6436 (2013.01); C12Y 101/01041 (2013.01); C12Y 101/0302 (2013.01); C12Y 102/01003 (2013.01); C12Y 203/01023 (2013.01); C12Y 401/01001 (2013.01); C12Y 604/01002 (2013.01);
Abstract

The present disclosure relates to genetically engineered host cells and methods of producing a lipid-derived compound by employing such host cells. In particular embodiments, the host cell includes a first mutant gene encoding a cytoplasmic tRNA thiolation protein. Optionally, the host cell can include other mutant genes for decreasing fatty alcohol catabolism, decreasing re-importation of secreted fatty alcohol, or displaying other useful characteristics, as described herein.


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