The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
Nov. 09, 2020
Applicant:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Inventors:
Anthony Quinn, Chestnut Hill, MA (US);
Alex J. Harvey, Athens, GA (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/20 (2006.01); A61K 38/46 (2006.01); A01K 67/027 (2006.01); A61K 31/194 (2006.01); A61K 38/38 (2006.01);
U.S. Cl.
CPC ...
C12N 9/20 (2013.01); A01K 67/0278 (2013.01); A61K 31/194 (2013.01); A61K 38/385 (2013.01); A61K 38/465 (2013.01); C12Y 301/01013 (2013.01); A01K 2217/052 (2013.01); A01K 2227/30 (2013.01); A01K 2267/01 (2013.01); C12N 2740/10041 (2013.01);
Abstract
The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.