The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
Mar. 24, 2020
Wisconsin Alumni Research Foundation, Madison, WI (US);
Helen Blackwell, Middleton, WI (US);
Joseph Vasquez, Madison, WI (US);
Yiftah Tal Gan, Reno, NV (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular inare provided. Compounds provided are racemic, non-racemic or substantially enantiomerically pure cyclic peptides of formula I: or salts or solvates thereof, where variables R, W, X, X, and Z and are as described in the specification and Lis a divalent linker which contains 1-12 carbon atoms, optionally 1-4 oxygen atoms, optionally one or two carbon-carbon double bonds, and hydrogen atoms to satisfy valency. Certain dimers of the cyclic peptides are also provided. One or more cylic peptides or dimers thereof herein can be employed to inhibit QS and to thus inhibit virulence inbacteria. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful in treating infections ofbacteria. Methods for treating such bacterial infections are also provided.