The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
Aug. 03, 2020
Applicant:
New York University, New York, NY (US);
Inventors:
Paramjit S. Arora, Cold Spring Harbor, NY (US);
Brooke Bullock Lao, Leesville, SC (US);
Richard Bonneau, New York, NY (US);
Kevin Drew, Austin, TX (US);
Assignee:
NEW YORK UNIVERSITY, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/08 (2006.01); C07C 29/80 (2006.01); C07C 29/88 (2006.01);
U.S. Cl.
CPC ...
C07D 241/08 (2013.01); C07C 29/80 (2013.01); C07C 29/88 (2013.01);
Abstract
The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).