The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
May. 17, 2018
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Cornell University, Ithaca, NY (US);
Michelle S. Bradbury, New York, NY (US);
Feng Chen, New York, NY (US);
Ulrich Wiesner, Ithaca, NY (US);
Kai Ma, Ithaca, NY (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Cornell University, Ithaca, NY (US);
Abstract
Described herein are nanoprobes comprising ultrasmall aminated and cRGDY-conjugated nanoparticles labeled with Zirconium-89 (Zr) and methods of their use. The provided compositions are renally clearable and possess suitable blood circulation half-time, high tumor active targeting capability, dominant renal clearance, low liver accumulation, and a high tumor-to-background ratio. The described nanoprobes exhibit great potential as 'target-or-clear' tracers to human subjects for systemic targeted imaging (or treatment) of cancer.