The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 24, 2023

Filed:

Sep. 23, 2019
Applicants:

Biontech SE, Mainz, DE;

Tron—translationale Onkologie an Der Universitätsmedizin Der Johannes Gutenberg—universität Mainz Ggmbh, Mainz, DE;

Inventors:

Ugur Sahin, Mainz, DE;

Heinrich Haas, Mainz, DE;

Sebastian Kreiter, Mainz, DE;

Mustafa Diken, Mainz, DE;

Daniel Fritz, Mainz, DE;

Martin Meng, Mainz, DE;

Lena Mareen Kranz, Mainz, DE;

Kerstin Reuter, Darmstadt, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/00 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0033 (2013.01); A61K 9/1272 (2013.01); A61K 39/0011 (2013.01); A61K 48/0025 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55555 (2013.01);
Abstract

The present invention is in the field of immunotherapy, in particular tumor immunotherapy. The present invention provides pharmaceutical formulations for delivering RNA to antigen presenting cells such as dendrite cells (DCs) in the spleen after systemic administration. In particular, the formulations described herein enable to induce an immune response after systemic administration of antigen-coding RNA.


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