The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
Jul. 30, 2010
Harald Rau, Heidelberg, DE;
Ulrich Hersel, Heidelberg, DE;
Mathias Krusch, Hirschhorn, DE;
Dirk Vetter, Heidelberg, DE;
Tobias Voigt, Heidelberg, DE;
Harald Rau, Heidelberg, DE;
Ulrich Hersel, Heidelberg, DE;
Mathias Krusch, Hirschhorn, DE;
Dirk Vetter, Heidelberg, DE;
Tobias Voigt, Heidelberg, DE;
Ascendis Pharma A/S, Hellerup, DE;
Abstract
The present invention relates to biodegradable polyethylene glycol based water-insoluble hydrogels comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the backbone moieties further comprising reactive functional groups, wherein the water-insoluble hydrogel is further characterized in that the ratio between the time period for the complete degradation of the hydrogel by hydrolysis of the degradable bonds into water-soluble degradation products comprising one or more backbone moieties and the time period for the release of the first 10 mol-% of water-soluble degradation products comprising one or more backbone moieties based on the total amount of backbone moieties in the hydrogel is greater than 1 and equal to or less than 2. The invention further relates to conjugates of such hydrogels with ligands or ligating groups, prodrugs and pharmaceutical compositions as well as their use in a medicament.