The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 2023
Filed:
Dec. 04, 2019
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Lynn Macdonald, Harrison, NY (US);
Sean Stevens, Del Mar, CA (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Margaret Karow, Santa Rosa Valley, CA (US);
John McWhirter, Hastings-on-Hudson, NY (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human Vgene segment, a plurality of human Dgene segments and a plurality of human Jgene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.