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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11559049 B1

PDFFull Text
Date of Patent:
Jan. 24, 2023

Filed:

Jan. 12, 2018

Antibody producing non-human animals

Applicant:

Merus N.v., Utrecht, NL;

Inventors:

Ton Logtenberg, Driebergen, NL;

Mark Throsby, Utrecht, NL;

Robert A. Kramer, Utrecht, NL;

Rui D. Pinto, Utrecht, NL;

Cornelis A. De Kruif, De Bilt, NL;

Erwin Houtzager, Zeist, NL;

Assignee:

Merus N.V., Utrecht, NL;

Attorney:

Morrison & Foerster LLP

Primary Examiner:

Anne Marie S Wehbe

Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/85 (2006.01); C07K 16/00 (2006.01); C07K 16/46 (2006.01); C07K 14/47 (2006.01); C07K 16/10 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); G01N 33/569 (2006.01); C07K 16/24 (2006.01); C12P 21/00 (2006.01); C07K 16/12 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A01K 67/027 (2013.01); A01K 67/0278 (2013.01); C07K 16/00 (2013.01); C07K 16/462 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/052 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); C07K 14/47 (2013.01); C07K 16/005 (2013.01); C07K 16/10 (2013.01); C07K 16/1282 (2013.01); C07K 16/22 (2013.01); C07K 16/248 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); C07K 2317/10 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/52 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/64 (2013.01); C07K 2317/76 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C12P 21/00 (2013.01); G01N 33/56966 (2013.01);
Abstract

Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.

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