The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 17, 2023

Filed:

Aug. 09, 2020
Applicant:

Inscripta, Inc., Boulder, CO (US);

Inventors:

Stephen Federowicz, Boulder, CO (US);

Deanna Church, Boulder, CO (US);

Michael Graige, Boulder, CO (US);

Assignee:

Inscripta, Inc., Boulder, CO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/19 (2006.01); C12N 15/10 (2006.01); C12N 15/90 (2006.01); C12N 9/22 (2006.01); C12N 15/81 (2006.01); C40B 50/04 (2006.01); C40B 40/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C12N 9/22 (2013.01); C12N 15/815 (2013.01); C12N 15/90 (2013.01); C12N 2310/3517 (2013.01); C40B 40/02 (2013.01); C40B 50/04 (2013.01);
Abstract

The present disclosure methods for identifying binding partners using cell surface display libraries, where the cells of the library display engineered peptides on their cell surfaces for identification of peptides that bind to targets of interest. The engineered peptides are preferably expressed in the cells under conditions that provide both secretion and display of the engineered peptides on the cell surfaces, thus providing access of the engineered peptides to identify potential binding pairs. The cell libraries cab be engineered using an automated editing system that provides for one or more targeted edits per cell.


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