The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2023
Filed:
Jan. 18, 2018
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Yair Reisner, Houston, TX (US);
Esther Bachar-Lustig, Rehovot, IL;
Shlomit Reich-Zeliger, Rehovot, IL;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C12N 5/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); A61P 35/04 (2018.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C07K 16/3084 (2013.01); C07K 16/32 (2013.01); C12N 5/0087 (2013.01); A61K 38/00 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/505 (2013.01); C12N 2510/00 (2013.01);
Abstract
An isolated cytotoxic T-lymphocyte (CTL), said CTL being a tolerance inducing cell and substantially depleted of alloreactivity, and wherein said CTL does not comprise a central memory T-lymphocyte (Tcm) phenotype, the CTL being transduced to express a cell surface receptor comprising a T cell receptor signaling module, is disclosed. Methods of generating same and using same are also disclosed.