The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 2023
Filed:
Jul. 28, 2021
Viela Bio, Inc., Gaithersburg, MD (US);
Anthony Coyle, Boston, MA (US);
Manuel Baca, Gaithersburg, MD (US);
Thomas Thisted, Gaithersburg, MD (US);
Stacey Drabic, Gaithersburg, MD (US);
Luba Grinberg, Gaithersburg, MD (US);
Shabazz Novarra, Gaithersburg, MD (US);
Vaheh Oganesyan, Gaithersburg, MD (US);
Ronald Herbst, Gaithersburg, MD (US);
David Kenneth Spencer, Gaithersburg, MD (US);
Viela Bio, Inc., Gaithersburg, MD (US);
Abstract
The present invention provides Tenascin-3 FnIII domain-based scaffolds that specifically bind to CD40L. The invention further provides engineered variants with increased affinity for the target. The present invention is also related to engineered scaffolds as prophylactic, diagnostic, or therapeutic agents, in particular for therapeutic uses against SLE and other autoimmune diseases and conditions.