Method for preparing 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxylquinoline 3-carbonitrile

Abstract

The present invention relates to the technical field of pharmaceutical synthesis, and in particular, to a method for preparing 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy) phenyl]amino]-7-ethoxylquinoline 3-carbonitrile. In the present invention, Compound 3 and Compound 2 react in the presence of a sulfonic compound to give Compound 4; Compound 4, 4-nitro-3-ethoxylphenylamine and triethyl orthoformate react by heating at reflux to give a solid intermediate; the solid intermediate and a Lewis acid are heated for a ring-closing reaction to give Compound 5; Compound 5, hydrazine hydrate and activated carbon react in the presence of a catalyst to give Compound 1, which is (6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy) phenyl]amino]-7-ethoxylquinoline 3-carbonitrile). The present invention has advantages of a short reaction route, a high yield and simple procedures, requires no extreme reaction condition, and features higher cost-efficiency and suitability for industrial manufacture.