The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 17, 2023

Filed:

Apr. 02, 2019
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Emery N. Brown, Brookline, MA (US);

Patrick L. Purdon, Somerville, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); A61B 5/00 (2006.01); A61K 31/13 (2006.01); A61K 31/137 (2006.01); A61K 31/165 (2006.01); A61K 31/522 (2006.01); A61K 45/06 (2006.01); A61B 5/316 (2021.01); A61B 5/369 (2021.01); A61K 31/4458 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4821 (2013.01); A61B 5/316 (2021.01); A61B 5/369 (2021.01); A61K 31/13 (2013.01); A61K 31/137 (2013.01); A61K 31/165 (2013.01); A61K 31/4458 (2013.01); A61K 31/522 (2013.01); A61K 45/06 (2013.01); A61K 9/0019 (2013.01);
Abstract

The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.


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