The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2023
Filed:
Jan. 18, 2018
Applicant:
Fred Hutchinson Cancer Center, Seattle, WA (US);
Inventors:
James M. Olson, Seattle, WA (US);
Zachary Crook, Bothell, WA (US);
Philip H. Bradley, Seattle, WA (US);
Assignee:
FRED HUTCHINSON CANCER CENTER, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 14/47 (2006.01); G16B 15/20 (2019.01); G16B 15/30 (2019.01);
U.S. Cl.
CPC ...
C07K 14/4703 (2013.01); G16B 15/20 (2019.02); G16B 15/30 (2019.02); A61K 38/00 (2013.01); C07K 2319/10 (2013.01);
Abstract
Described herein are peptides and variants and mutants thereof capable of interacting with TEAD, disrupting the HIPPO pathway, or modulating the activity or function of TEAD interactions in a cell. Pharmaceutical compositions and uses of peptides, as well as methods of designing and manufacturing such peptides, to treat cancer, tumor, or any other disease/condition associated with a dysregulated HIPPO pathway or uncontrolled cell growth are also described herein.