The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2023
Filed:
Apr. 24, 2015
Applicant:
Eisai R&d Management Co., Ltd., Tokyo, JP;
Inventors:
Ryo Ohori, Gifu, JP;
Kanta Horie, Gifu, JP;
Assignee:
Eisai R&D Management Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 9/19 (2006.01); A61K 38/00 (2006.01); A61K 47/02 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1833 (2013.01); A61K 9/19 (2013.01); A61K 38/00 (2013.01); A61K 47/02 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01);
Abstract
An object of the present invention is to provide a lyophilized formulation having improved storage stability of hepatic growth factor compared to conventional lyophilized formulations. The present invention provides a lyophilized formulation comprising (1) a hepatic growth factor, (2) trehalose and (3) one or more compounds selected from the group consisting of arginine, histidine, lysine, meglumine, glutamic acid, aspartic acid, proline, creatine, creatinine, tris(hydroxymethyl)aminomethane, and pharmaceutically acceptable salts thereof.