The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2023
Filed:
Oct. 15, 2020
The University of Tokyo, Tokyo, JP;
School Corporation, Azabu Veterinary Medicine Educational Institution, Sagamihara, JP;
Kenya Honda, Tokyo, JP;
Koji Atarashi, Tokyo, JP;
Takeshi Tanoue, Tokyo, JP;
Masahira Hattori, Tokyo, JP;
Hidetoshi Morita, Sagamihara, JP;
The University of Tokyo, Tokyo, JP;
School Corporation, Azabu Veterinary Medicine Educational Institution, Sagamihara, JP;
Abstract
Provided herein are methods of treating graft-versus-host disease in a subject by administering pharmaceutical compositions containing bacterial strains of the Clostridia class. Also described herein are exemplary human-derived bacteria belonging to the Clostridia class, combinations of which have been shown to induce accumulation of regulatory T cells (Treg cells) in the colon and suppress immune functions, and are therefore useful for mitigating pathological immune responses. Pharmaceutical compositions containing these and/or related bacteria can be used to prevent and treat immune-mediated diseases such as graft-versus-host disease.