The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 10, 2023
Filed:
Aug. 20, 2018
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Inventors:
Jingxing Ou, Bethesda, MD (US);
Wei Li, Potomac, MD (US);
Kiyoharu Josh Miyagishima, Laurel, MD (US);
Assignee:
THE USA, AS REPRESENTED BY THE SECRETARY, DHHS, Bethesda, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); A61K 31/336 (2006.01); A61K 31/34 (2006.01); A61K 38/08 (2019.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4985 (2013.01); A61K 31/336 (2013.01); A61K 31/34 (2013.01); A61K 38/08 (2013.01); A61K 45/06 (2013.01);
Abstract
A composition for preserving viability of cells, tissues, or organs at a low temperature is provided. The composition includes a mitochondrial uncoupling agent, at least one protease inhibitor, and a reducing agent. Methods to protect cells, tissues, or organs from exposure to cold and other metabolic stress are also provided.