The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2023

Filed:

Sep. 11, 2020
Applicants:

Valo Health, Inc., Boston, MA (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Kenneth W. Bair, Wellesley, MA (US);

Timm R. Baumeister, Cambridge, MA (US);

Alexandre J. Buckmelter, Acton, MA (US);

Karl H. Clodfelter, Brighton, MA (US);

Peter Dragovich, South San Francisco, CA (US);

Francis Gosselin, South San Francisco, CA (US);

Bingsong Han, Westwood, MA (US);

Jian Lin, Acton, MA (US);

Dominic J. Reynolds, Stoneham, MA (US);

Bruce Roth, South San Francisco, CA (US);

Chase C. Smith, Rutland, MA (US);

Zhongguo Wang, Lexington, MA (US);

Po-Wai Yuen, Beijing, CN;

Xiaozhang Zheng, Lexington, MA (US);

Assignees:

Valo Health, Inc., Boston, MA (US);

Genentech, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 491/04 (2006.01); C07D 495/04 (2006.01); A61K 31/4355 (2006.01); A61K 31/4365 (2006.01); A61K 31/437 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4355 (2013.01); A61K 31/437 (2013.01); A61K 31/4365 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01); C07D 491/048 (2013.01); C07D 495/04 (2013.01);
Abstract

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:


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