The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2023

Filed:

Dec. 22, 2017
Applicant:

Ariagen, Inc., Menlo Park, CA (US);

Inventors:

Luqing Yang, Shenzhen, CN;

Guodong Li, Shenzhen, CN;

Suoming Zhang, Shenzhen, CN;

Assignee:

ARIAGEN, INC., Menlo Park, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/044 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 409/06 (2006.01); C07D 413/06 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 417/14 (2006.01); A61K 31/4245 (2006.01); A61P 35/04 (2006.01); A61K 31/404 (2006.01); A61K 31/4196 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/497 (2006.01); A61K 31/5377 (2006.01); A61K 31/7056 (2006.01); A61K 31/506 (2006.01); A61K 31/4025 (2006.01); A61P 35/00 (2006.01); C07D 209/12 (2006.01); A61K 31/4178 (2006.01); A61K 31/4439 (2006.01); C07D 419/14 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4245 (2013.01); A61K 31/404 (2013.01); A61K 31/4025 (2013.01); A61K 31/4178 (2013.01); A61K 31/4196 (2013.01); A61K 31/427 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/7056 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07D 209/12 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01); C07D 417/06 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 419/14 (2013.01); C07H 19/044 (2013.01);
Abstract

The disclosure discloses an aryl hydrocarbon receptor modulators of formula (I), and pharmaceutically acceptable salts, two Ris independently H, or two Rtogether form ═O or ═N—W—R; A is a Cto Caromatic ring, or a Cto Cheteroaromatic ring containing 1 to 5 heteroatom from N, O and S, or 4 to 7 membered non-aromatic heterocyclic ring containing 1 to 3 heteroatom from N, O and S and C═N, which are with no substituent or substituted by 1 or 3 R; Q is R, or a Cto Caromatic ring or a Cto Cheteroaromatic ring containing 1 to 5 heteroatom selected from N, O and S, which are with no substituent or substituted by 1 or 3 R; R is Rconnected with C or Rconnected with N.


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