The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 10, 2023

Filed:

Jul. 23, 2019
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Szu-Wen Wang, Irvine, CA (US);

Tae Il Kim, Irvine, CA (US);

Kenneth J. Shea, Irvine, CA (US);

Krista Fruehauf, Irvine, CA (US);

Edward L. Nelson, Irvine, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5138 (2013.01); A61K 9/5169 (2013.01);
Abstract

For applications in drug delivery, 'smart' materials have been designed to respond to conditions within microenvironments of tissues or cells. The present invention features stimuli-responsive cross-linked hydrogels that respond to specific metabolites of disease. For example, protein-polymer materials of the present invention are configured to release their drug cargo upon encountering the higher lactate concentrations within tumor microenvironments.


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