The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2023

Filed:

Jul. 17, 2018
Applicant:

Tsinghua University, Haidian District Beijing, CN;

Inventors:

Zhen Chen, Beijing, CN;

Dehua Liu, Beijing, CN;

Assignee:

Tsinghua University, Beijing, CN;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/16 (2006.01); C12N 1/20 (2006.01); C12P 7/18 (2006.01); C12N 9/04 (2006.01); C12N 9/88 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
C12P 7/18 (2013.01); C12N 1/16 (2013.01); C12N 1/20 (2013.01); C12N 9/0006 (2013.01); C12N 9/88 (2013.01); C12N 9/93 (2013.01); C12Y 101/01202 (2013.01); C12Y 402/01116 (2013.01); C12Y 602/01036 (2013.01); C12Y 604/00 (2013.01); C12Y 604/01002 (2013.01);
Abstract

Provided is a method for producing 1,3-propanediol by means of fermentation of a recombinant microorganism. First, a recombinant microorganism is provided; the recombinant microorganism can overexpress acetyl-CoA carboxylase genes: accBC and accDA, a malonyl-CoA synthetase gene: mcr, a 3-hydroxypropionyl-CoA synthetase gene: pcs, a 3-hydroxypropionyl-CoA reductase gene: pduP, and a 1,3-propanediol reductase gene: yqhD. The recombinant microorganism is subjected to fermentation culture in a flask or fermentor using glucose ad as raw material to obtain the 1,3-propanediol. The recombinant microorganism can utilize low-cost glucose, sucrose, molasses, xylose and the like as raw material in the fermentation process, without additional expensive vitamin B12. Thus, cost of the production is significantly reduced, and there is a promising prospect in market.


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