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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11542526 B1

PDFFull Text
Date of Patent:
Jan. 03, 2023

Filed:

Feb. 21, 2020

Oncolytic adenoviral vector and methods of use

Applicant:

Unleash Immuno Oncolytics, Inc., St. Louis, MO (US);

Inventors:

David T. Curiel, St. Louis, MO (US);

Osvaldo Podhajcer, Ciudad Autonoma de Buenos Aires, AR;

Maria Veronica Lopez, Buenos Aires, AR;

Assignee:

Unleash Immuno Oncolytics, Inc., St. Louis, MO (US);

Attorneys:

Casimir Jones, S.C.

Rikki A. Hullinger

Peter J. Schlueter

Primary Examiner:

Barry A Chestnut

Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); A61K 35/761 (2015.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/761 (2013.01); A61K 45/06 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 48/00 (2013.01); C12N 2710/10022 (2013.01); C12N 2710/10043 (2013.01);
Abstract

Provided herein is a conditionally-replicating serotype 5 adenovirus or adenoviral vector expressing a mutant E1A protein under control of a promoter that is responsive to hypoxia and inflammation and one or more immune modulators under control of a tumor-specific promoter. The adenovirus or adenoviral vector also comprises serotype 3 fiber and hexon proteins. Also provided is a method of inducing cytotoxicity in tumor cells using a composition containing the adenovirus or adenoviral vector.

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Curiel, David. (2023). Oncolytic adenoviral vector and methods of use (U.S. Patent No. 11542526). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11542526

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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