The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Jun. 05, 2020
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Marianne Ravn Møller, Kgs. Lyngby, DK;
Heidi Rye Hudlebusch, Brønshøj, DK;
Lykke Pedersen, Copenhagen NV, DK;
Erik Daa Funder, Hilleroed, DK;
Christoffer Sondergaard, Horsholm, DK;
Jette Dam Hedegaard, Horsholm, DK;
Alexander Herbert Stephan, Riehen, CH;
Peter Hagedorn, Hørsholm, DK;
Assignee:
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61P 25/28 (2018.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/351 (2013.01); C12N 2320/32 (2013.01);
Abstract
The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.