The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Jul. 21, 2015
Novartis Ag, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Jennifer Brogdon, Cambridge, MA (US);
Carla Guimaraes, Cambridge, MA (US);
John Hastewell, Cambridge, MA (US);
Andreas Loew, Cambridge, MA (US);
Novartis AG, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Sortase molecules and methods described herein allow for the construction of a CAR or CAR member, e.g., in situ, on a CARX, e.g., CART, cell. For example, sortase mediated transfer of an antigen binding domain, e.g., a scFv, onto a CAR member having a sortase acceptor motif in place of an antigen binding domain can provide for a complete CAR member on a cell wherein the cell does not comprise nucleic acid that encodes the complete CAR member.