The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Nov. 19, 2020
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Curtis Hewitt, Austin, TX (US);
Richard Jude Samulski, Chapel Hill, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); C07K 14/005 (2006.01); C12N 15/86 (2006.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); C07K 14/005 (2013.01); C12N 15/86 (2013.01); C12N 15/8645 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14162 (2013.01); C12N 2750/14322 (2013.01); C12N 2750/14352 (2013.01); C12N 2820/60 (2013.01);
Abstract
This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.