The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Nov. 22, 2019
Emulate, Inc., Boston, MA (US);
Remi Villenave, Boston, MA (US);
Carolina Lucchesi, Westwood, MA (US);
Justin Nguyen, Medford, MA (US);
Catherine Karalis, Brookline, MA (US);
Geraldine Hamilton, Boston, MA (US);
Buket Baddal, Brookline, MA (US);
Michael Salmon, Boston, MA (US);
EMULATE, INC., Boston, MA (US);
Abstract
The present invention relates to microfluidic fluidic systems and methods for the in vitro modeling diseases of the lung and small airway. In one embodiment, the invention relates to a system for testing responses of a microfluidic Small Airway-on-Chip infected with one or more infectious agents (e.g. respiratory viruses) as a model of respiratory disease exacerbation (e.g. asthma exacerbation). In one embodiment, this disease model on a microfluidic chip allows for a) the testing of anti-inflammatory and/or anti-viral compounds introduced into the system, as well as b) the monitoring of the participation, recruitment and/or movement of immune cells, including the transmigration of cells. In particular, this system provides, in one embodiment, an in-vitro platform for modeling severe asthma as 'Severe Asthma-on-Chip.' In some embodiments, this invention provides a model of viral-induced asthma in humans for use in identifying potentially effective treatments.