The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Oct. 21, 2016
Applicant:
Amniotics Ab, Lund, SE;
Inventors:
Assignee:
Amniotics AB, Lund, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0789 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0647 (2013.01); C12N 2501/01 (2013.01); C12N 2502/088 (2013.01); C12N 2506/02 (2013.01); C12N 2506/03 (2013.01); C12N 2506/11 (2013.01);
Abstract
Maturation signals provided via cyclic adenosine monophosphate (cAMP)/xchangeroteinsctivated byAMP (Epac) signaling during in vitro generation of blood cells from reprogrammed cells or pluripotent stem cells achieve superior function of hematopoietic cells differentiated from stem cells. The cAMP/Epac signaling enables an increased efficiency of production of precursor to blood and to blood cells. These generated blood cells can be utilized for therapeutics, treatments, disease prevention, drug discovery, personalized medicine, regenerative medicine, cell and tissue generation, universal donor banks and related methods and compositions.