The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Nov. 26, 2018
Applicant:
Memorial Sloan-kettering Cancer Center, New York, NY (US);
Inventors:
Lorenz Studer, New York, NY (US);
Nadja Zeltner, Weehawken, NJ (US);
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0793 (2010.01); C12N 5/0775 (2010.01); C12N 5/074 (2010.01); A61P 25/28 (2006.01); A61K 35/30 (2015.01);
U.S. Cl.
CPC ...
C12N 5/062 (2013.01); A61K 35/30 (2013.01); A61P 25/28 (2018.01); C12N 5/0667 (2013.01); C12N 5/0696 (2013.01); C12N 2501/115 (2013.01); C12N 2501/13 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/415 (2013.01); C12N 2501/42 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2533/52 (2013.01); C12N 2533/90 (2013.01);
Abstract
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells (e.g., human stem cells) into proprioceptors, proprioceptors generated by such methods, and compositions comprising such proprioceptors. The presently disclosed subject matter also provides for uses of such proprioceptors for preventing and/or treating disorders of proprioceptor neurons and/or neurodegenerative disorders (e.g., Friedreich's Ataxia).