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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11542430 B1

PDFFull Text
Date of Patent:
Jan. 03, 2023

Filed:

Mar. 30, 2020

Method for preparing fluorescent-encoded microspheres coated with metal nanoshells

Applicant:

Hangzhou Shinedo Biotech Co., Ltd., Hangzhou, CN;

Inventors:

Jianqiu Fang, Anji Huzhou, CN;

Chunmei Zhong, Hangzhou, CN;

Wanwan Li, Hangzhou, CN;

Assignee:

HANGZHOU SHINEDO BIOTECH CO., LTD., Hangzhou, CN;

Attorney:

NZ Carr Law Office

Primary Examiner:

C Melissa Koslow

Int. Cl.
CPC ...
C09K 11/02 (2006.01); B01F 23/43 (2022.01); B01F 23/40 (2022.01); B01F 23/41 (2022.01); B01F 33/45 (2022.01); B01J 13/04 (2006.01); B01J 13/02 (2006.01); B82Y 15/00 (2011.01); B82Y 20/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); G01N 21/25 (2006.01); B01F 23/00 (2022.01);
U.S. Cl.
CPC ...
C09K 11/025 (2013.01); B01F 23/4105 (2022.01); B01F 23/43 (2022.01); B01F 23/49 (2022.01); B01F 33/45 (2022.01); B01J 13/02 (2013.01); B01J 13/04 (2013.01); B01F 23/06 (2022.01); B01F 23/4146 (2022.01); B01F 23/48 (2022.01); B82Y 15/00 (2013.01); B82Y 20/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); G01N 21/25 (2013.01); G01N 2021/258 (2013.01);
Abstract

A method for preparing fluorescent-encoded microspheres coated with metal nanoshells is disclosed herein. By using SPG method, metal nano-material modified with a certain ligand is used as a new surfactant in the emulsification process, and different kinds and different amounts of fluorescent materials are doped into polymer microspheres to prepare fluorescent-encoded microspheres with different fluorescent-encoded signals and uniformly coated metal nanoshells in one step. The prepared fluorescent-encoded microsphere comprises a metal nanoshell, a polymer, and a fluorescent-encoded material. The fluorescent-encoded microsphere has a particle size of 1 μm˜20 μm, CV of less than 10%, which can be used for protein/nucleic acid detection. The preparation method has the advantages of simple process, high surface coating rate, good uniformity and controllable LSPR peaks, which can solve the problems of existing commonly used metal nanoshell coating methods such as low surface coating rate, poor uniformity, complex preparation process and uncontrollable local surface plasmon resonance (LSPR) peaks, etc.

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