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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11542311 B1

PDFFull Text
Date of Patent:
Jan. 03, 2023

Filed:

Mar. 05, 2018

Fusion protein, preparation method therefor and application thereof in preparing ophthalmic disease treatment, anti-inflammation and anti-tumor medicament

Applicant:

Jiangsu Rongtai Biotech Co., Ltd., Nanjing, CN;

Inventor:

Hanmei Xu, Nanjing, CN;

Assignee:

JIANGSU RONGTAI BIOTECH CO., LTD., Nanjing, CN;

Attorney:

Zhihua Han

Primary Examiner:

Brian Gangle

Assistant Examiner:

Andrea K McCollum

Int. Cl.
CPC ...
C07K 14/54 (2006.01); A61P 27/02 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61K 38/00 (2006.01); C07K 14/475 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5406 (2013.01); A61K 38/00 (2013.01); A61P 19/02 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); C07K 14/475 (2013.01); C07K 2319/30 (2013.01);
Abstract

The invention discloses a fusion protein, a preparation method thereof and application thereof in preparing ophthalmic disease treatment, anti-inflammation and anti-tumor medicament, and belongs to the field of biopharmaceutical technology. The present invention uses a flexible (F) or rigid (R) linker to fuse two polypeptides to respectively obtain two bifunctional fusion proteins, namely two multi-functional fusion protein macromolecules obtained by linking antiangiogenesis polypeptides HM-3, interleukin 4 and immunoglobulin Fc fragments via an amino acid linker, which can improve drug efficacy, prolong half-life and enhance stability, has the characteristics of strong effect, low toxicity and the like, and can be used for the prevention and treatment of solid tumors and various types of inflammations and neovascular ophthalmic diseases. The fusion protein is expressed in a eukaryotic cell by a genetic engineering method and purified by affinity chromatography or the like.

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Xu, Hanmei. (2023). Fusion protein, preparation method therefor and application thereof in preparing ophthalmic disease treatment, anti-inflammation and anti-tumor medicament (U.S. Patent No. 11542311). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11542311

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