The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2023

Filed:

Feb. 28, 2019
Applicant:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Inventors:

Robert H. Mach, Wallingford, PA (US);

Sean W. Reilly, Philadelphia, PA (US);

Mehran Makvandi, Philadelphia, PA (US);

Laura Puentes, Philadelphia, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/107 (2006.01); C07F 5/02 (2006.01); C07B 59/00 (2006.01); C07D 237/32 (2006.01); C07D 403/10 (2006.01); C07D 471/10 (2006.01); C07D 487/10 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07F 5/025 (2013.01); C07B 59/002 (2013.01); C07D 237/32 (2013.01); C07D 403/10 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); G01N 33/574 (2013.01); G01N 33/6896 (2013.01); C07B 2200/05 (2013.01);
Abstract

The present disclosure provides compounds of Formula (I) or (II), pharmaceutically acceptable salt, isotopic variant, stereoisomer, or a mixture thereof. Also provided are pharmaceutical compositions comprising a compound, methods of treating a poly(ADP-ribose)polymerase-1-mediated disease or disorder in a subject, methods of detecting a poly(ADP-ribose)polymerase-1-mediated neurodegenerative disease or disorder, or methods of monitoring cancer treatment in a subject. In some embodiments, the poly(ADP-ribose)polymerase-1-mediated disease or disorder is a neurodegenerative disease or cancer.


Find Patent Forward Citations

Mach, Robert. (2023). Low affinity poly(ad-ribose) polymerase 1 dependent cytotoxic agents (U.S. Patent No. 11542282). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11542282

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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