The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 03, 2023

Filed:

Feb. 28, 2020
Applicants:

Children's Hospital Medical Center, Cincinnati, OH (US);

The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);

Inventors:

Daniel T. Starczynowski, Cincinnati, OH (US);

Craig J. Thomas, Gaithersburg, MD (US);

Garrett Rhyasen, Burlington, MA (US);

Katelyn Melgar, Cincinnati, OH (US);

Morgan MacKenzie Walker, New haven, CT (US);

Jian-kang Jiang, Columbia, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/437 (2006.01); C07D 471/04 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/496 (2013.01);
Abstract

Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same.


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