The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Apr. 13, 2016
Applicants:
Ganymed Pharmaceuticals Gmbh, Mainz, DE;
Tron—translationale Onkologie an Der Universitatsmedizin Der Johannes Gutenberg-universitat Mainz Ggmbh, Mainz, DE;
Inventors:
Ugur Sahin, Mainz, DE;
Ozlem Tureci, Mainz, DE;
Korden Walter, Saulheim, DE;
Maria Kreuzberg, Mainz, DE;
Rita Mitnacht-Kraus, Friedberg, DE;
Fabrice Le Gall, Mainz, DE;
Stefan Jacobs, Mainz-Kastel, DE;
Assignees:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/68 (2017.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01); A61K 31/40 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6859 (2017.08); A61K 31/40 (2013.01); A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61K 47/6863 (2017.08); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07K 16/28 (2013.01); C07K 16/303 (2013.01); C07K 16/3046 (2013.01); A61K 2039/505 (2013.01); A61K 2039/627 (2013.01); C07K 2317/24 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01);
Abstract
The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.