The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2023
Filed:
Jan. 12, 2018
Celdara Medical, Llc, Lebanon, NH (US);
Celldex Therapeutics, Inc., Hampton, NJ (US);
Terrance A. Stadheim, Lyme, NH (US);
Joana M. Murad, Hanover, NH (US);
Jake Reder, Hanover, NH (US);
Henry C. Marsh, Jr., Reading, MA (US);
Li-Zhen He, Allentown, PA (US);
Tibor Keler, Pipersville, PA (US);
CELDARA MEDICAL, LLC, Lebanon, NH (US);
CELLDEX THERAPEUTICS, INC., Hampton, NJ (US);
Abstract
The invention provides chimeric antigen receptors (CARs) that specifically bind to the T-cell immunoglobulin and mucin domain 1 (TIM-1) protein. The invention further relates to modified immune cells, e.g., T or NK cells, comprising such CARs, CAR-encoding nucleic acids, CAR-encoding vectors, and methods of making such compositions. The invention further relates to methods for therapeutic use of these CARs and modified immune cells for the treatment of a condition, disorder, or disease associated with cells expressing TIM-1 (e.g., cancer).