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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11541075 B1

PDFFull Text
Date of Patent:
Jan. 03, 2023

Filed:

Aug. 26, 2020

Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid

Applicant:

Anika Therapeutics, Inc., Bedford, MA (US);

Inventors:

Tamera B. Gooding, Jamaica Plain, MA (US);

Stephen J. Kennedy, Hudson, MA (US);

Charles H. Sherwood, Sudbury, MA (US);

Assignee:

Anika Therapeutics, Inc.;

Attorney:

Goodwin Procter LLP

Primary Examiner:

Layla D Berry

Int. Cl.
CPC ...
A61K 31/728 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/573 (2006.01); A61K 31/729 (2006.01); A61K 35/28 (2015.01); A61K 35/32 (2015.01); A61K 38/18 (2006.01); A61K 47/36 (2006.01); A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/38 (2006.01); A61L 27/48 (2006.01); A61L 27/52 (2006.01); A61L 27/56 (2006.01); C08L 5/08 (2006.01); A61K 45/06 (2006.01); A61M 5/178 (2006.01);
U.S. Cl.
CPC ...
A61K 31/728 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 31/573 (2013.01); A61K 31/729 (2013.01); A61K 35/28 (2013.01); A61K 35/32 (2013.01); A61K 38/1841 (2013.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); A61L 27/20 (2013.01); A61L 27/227 (2013.01); A61L 27/3817 (2013.01); A61L 27/3834 (2013.01); A61L 27/3843 (2013.01); A61L 27/48 (2013.01); A61L 27/52 (2013.01); A61L 27/56 (2013.01); A61M 5/178 (2013.01); C08L 5/08 (2013.01); A61L 2430/06 (2013.01);
Abstract

A method of treating a subject having a musculoskeletal disorder includes administering to a subject's articular site in need thereof an effective amount of a hyaluronic acid (HA) composition. In one embodiment, the HA composition includes an HA derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or O-acyl isourea, or both N-acylurea and O-acyl isourea. In another embodiment, the HA composition includes a crosslinked HA gel that is prepared by reacting an uncrosslinked HA with a biscarbodiimide in the presence of pH buffer in a range of between about 4 and about 8. The composite can optionally include at least one second bioactive agent other than the HA derivative, such as a steroid.

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