The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Dec. 24, 2010
Masami Suzuki, Shizuoka, JP;
Koichi Matsubara, Helios, SG;
Atsuhiko Kato, Shizuoka, JP;
Chie Kato, Shizuoka, JP;
Shinta Kobayashi, Helios, SG;
Yu Jau Chen, Helios, SG;
Masaki Yamazaki, Helios, SG;
Masami Suzuki, Shizuoka, JP;
Koichi Matsubara, Helios, SG;
Atsuhiko Kato, Shizuoka, JP;
Chie Kato, Shizuoka, JP;
Shinta Kobayashi, Helios, SG;
Yu Jau Chen, Helios, SG;
Masaki Yamazaki, Helios, SG;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
An objective of the present invention is to provide non-human animal models of cancer pathology, which mimic the hierarchical organization, cancer progression process, or biological property of human cancer tissues, and uses thereof. To achieve the objective described above, first, the present inventors transplanted cells of NOG-established cancer lines into NOG mice and morphologically observed the resulting tissue organization. As a result, the non-human animal models were demonstrated to exhibit pathologies (the hierarchical organization, cancer progression process, or biological properties of the cancer cells) similar to that of human cancer. Specifically, the present inventors succeeded in preparing non-human animal models exhibiting pathologies more similar to a human cancer, and cell culture systems using NOG-established cancer cell lines where the in vitro cell morphology is more similar to that of human cancer.