The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Sep. 23, 2021
Scribe Therapeutics Inc., Alameda, CA (US);
Benjamin Oakes, El Cerrito, CA (US);
Hannah Spinner, Boston, MA (US);
Sarah Denny, San Francisco, CA (US);
Brett T. Staahl, Tiburon, CA (US);
Kian Taylor, Atlanta, GA (US);
Katherine Baney, Berkeley, CA (US);
Isabel Colin, Oakland, CA (US);
Maroof Adil, Davis, CA (US);
Cole Urnes, Los Angeles, CA (US);
Sean Higgins, Alameda, CA (US);
Scribe Therapeutics Inc., Alameda, CA (US);
Abstract
Provided herein are Class 2 Type V CRISPR:gNA systems comprising Class 2 Type V CRISPR polypeptides (e.g. CasX), guide nucleic acids (gNA), and optionally donor template nucleic acids useful in the modification of a RHO gene. The systems are also useful for introduction into cells, for example eukaryotic cells having mutations in the rhodopsin protein. Also provided are methods of using such systems to modify cells having such mutations and utility in methods of treatment of a subject with a RHO-related disease, such as retinitis pigmentosa.