The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2022
Filed:
Oct. 28, 2016
Applicant:
Sung Kwang Medical Foundation, Seoul, KR;
Inventors:
Assignee:
Sung Kwang Medical Foundation, Seoul, KR;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); C12N 15/873 (2010.01); C12N 15/877 (2010.01); C12N 5/073 (2010.01); C12N 5/075 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0607 (2013.01); C12N 5/0604 (2013.01); C12N 5/0609 (2013.01); C12N 15/873 (2013.01); C12N 15/8775 (2013.01); C12N 2501/065 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2501/608 (2013.01); C12N 2510/04 (2013.01); C12N 2517/04 (2013.01);
Abstract
The present invention provides methods and compostions to improve the efficiency of somatic cell nuclear transfer (SCNT). There is increasing evidence that the epigenetic state of donor nuclei has a significant impact on potential of nuclear transfer embryos to develop into blastocysts, from which pluripotent stem cells are derived. Strategic application of histone agents, capable of altering epigenetic state such as methylation, allows zygotic activation and robust blastocyst generation.